The reference site for Rizatriptan

Rizatriptan (trade name Maxalt) is a 5-HT1 receptor agonist of the triptan class of drugs developed by Merck & Co. for the treatment of migraine headaches.

WHAT IS Rizatriptan?

Rizatriptan belongs to a group of drugs called triptans. It affects a certain natural chemical (serotonin) that constricts blood vessels in the brain, and it may also block other pain pathways in the brain.

Rizatriptan is primarily used to treat migraines. It helps to relieve headaches, pain and other symptoms of migraines, including sensitivity to light/sound, nausea, and vomiting.

Prompt treatment with this medication allows you to get back to your normal routine and may decrease your need for other pain medications. However, rizatriptan does not prevent future migraines or reduce how often you may get a headache.

Rizatriptan is sold under the brand names Maxalt® and Maxalt-MLT® in the US.

 

Brand Name(s): Maxalt; Maxalt-MLT
CAS nº: 145202-66-0
(ry zah TRIP tin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to rizatriptan and its correct use. Please read them carefully.

FDA Information

Rizatriptan was developed by Merck & Co. and obtained approval by the Food and Drug Administration (FDA) on June 29th 1998. It represents a second-generation triptan.

Rizatriptan is available only by prescription in the United States and Canada.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Rizatriptan is used to treat migraines. It helps to relieve headaches, pain and other symptoms of migraines, including sensitivity to light/sound, nausea, and vomiting.

Prompt treatment allows you to get back to your normal routine and may decrease your need for other pain medications. Despite this, rizatriptan does not prevent future migraines or reduce how often you may get a headache.

Rizatriptan belongs to a group of drugs called triptans, which work by affecting a certain natural chemical (serotonin) that constricts blood vessels in the brain. It may also block other pain pathways in the brain.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Rizatriptan is available in strengths of 5 and 10 mg as standard tablets and also in orally-disintegrating tablets (Maxalt-MLT®).

Take this medication exactly as it was prescribed for you and follow the instructions on your prescription label. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Take rizatriptan as soon as you notice headache symptoms, or after an attack has already begun.

Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to see if you have any serious side effects.

Take one rizatriptan tablet with a full glass of water.

To take rizatriptan orally disintegrating tablets (Maxalt-MLT®):

– Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil as you may damage it.

– Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve straight away.

– Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

– Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than 30 mg of rizatriptan in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.

Additionally, please contact your doctor if you have more than four headaches in one month (30 days).

What special precautions should I follow?

BEFORE TAKING RIZATRIPTAN:

Tell your doctor if you suffer from high blood pressure, liver disease, kidney disease, phenylketonuria (tablets may contain phenylalanine), coronary artery disease or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy. If you have any of these conditions, you may not be able to use rizatriptan, or you may need a dosage adjustment or special tests during treatment.

Do not use this medication if you are allergic to rizatriptan, or if you have a history of heart disease, angina (chest pain), blood circulation problems, history of a heart attack or stroke, ischemic bowel disease, severe or uncontrolled high blood pressure, or a headache that is not like other headaches you have had.

Do not use rizatriptan if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan®), tranylcypromine (Parnate®), rasagiline (Azilect®), selegiline (Eldepryl®, Emsam®), or phenelzine (Nardil®) in the past 14 days.

Do not use rizatriptan within 24 hours after taking any of the following medicines: almotriptan (Axert®), eletriptan (Relpax®), frovatriptan (Frova®), sumatriptan (Imitrex®), naratriptan (Amerge®), or zolmitriptan (Zomig®); or  ergot medicine such as methysergide (Sansert®), ergotamine (Ergomar®, Ergostat®, Cafergot®, Ercaf®, Wigraine®), dihydroergotamine (D.H.E. 45®, Migranal Nasal Spray®), ergonovine (Ergotrate®), methylergonovine (Methergine®).

Moreover, inform your doctor if you are using any of the following drugs: propranolol (Inderal®, InnoPran®); an antidepressant such as citalopram (Celexa®), duloxetine (Cymbalta®), escitalopram (Lexapro®), fluoxetine (Prozac®, Sarafem®), fluvoxamine (Luvox®), paroxetine (Paxil®), sertraline (Zoloft®), or venlafaxine (Effexor®); or another migraine medicine such as almotriptan (Axert®), eletriptan (Relpax®), frovatriptan (Frova®), sumatriptan (Imitrex®), naratriptan (Amerge®), or zolmitriptan (Zomig®). If you are using any of these drugs, you may not be able to use rizatriptan, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed above that can affect the mechanism of rizatriptan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

This medication falls into the FDA pregnancy category C. This means that it may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Your name may need to be listed on a rizatriptan pregnancy registry when you start using this medication.

Furthermore, it is not known whether rizatriptan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Rizatriptan can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

This medicine should not be given to anyone younger than 18 years old.

What should I do if I forget a dose?

Since rizatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using rizatriptan.

After taking a rizatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than 30 mg of rizatriptan in 24 hours.

What side effects can this medication cause?

Please get emergency medical help if you have any of these signs of an allergic reaction:

hives
difficulty breathing
swelling of your face, lips, tongue, or throat

Stop using rizatriptan and call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling
pain spreading to the arm or shoulder
nausea, vomiting or general ill feeling
sweating
sudden numbness or weakness (especially on one side of the body)
sudden headache
confusion, hallucinations or agitation
problems with vision, speech, or balance
fast heart rate
muscle stiffness
lack of coordination
sudden and severe stomach pain and bloody diarrhea
tingling and a pale or blue-colored appearance in your fingers or toes

Continue using rizatriptan and talk with your doctor if you have any of these less serious side effects:

dry mouth
upset stomach
mild headache (not a migraine)
feeling too warm or too cold
tremors or confusion
warmth or redness under your skin
pressure or heavy feeling in any part of your body
feeling of pain or pressure in your neck and throat
weakness, dizziness, sleepiness

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Try to always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed.If you have any questions, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

severe headache
blurred vision
trouble concentrating
chest pain
numbness
seizure (convulsions)
neck stiffness
tiredness
lack of coordination
feeling light-headed
fainting

Product Images

PICTURES OF RIZATRIPTAN PILLS

Below you will find images and specific information on the principal types of rizatriptan that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

 

Name: MAXALT®
Strength(s): 10 MG
Imprint: MAXALT | 10 mg
Manufacturer: MERCK & CO.

Name: MAXALT MLT® Orally Disintegrating
Strength(s): 5 MG
Imprint: ∆ (triangle)
Manufacturer: MERCK & CO.

Name: MAXALT MLT® Orally Disintegrating
Strength(s): 10 MG
Imprint: □ (square)
Manufacturer: MERCK & CO.

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